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By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are. Abstract. Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble. Acta Pharm. Mar;57(1) Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical.

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When oral route for administration of the drug is chosen then that drug should be sufficiently dissolved in gastric fluids for its proper absorption. By adding PVP to liquid medication, it would be possible to produce dry powder formulations containing liquid with a high concentration of drug. When drug dissolved in liquid etchnique is poured onto a porous carrier material, liquid gets absorbed in its internal structure, and after saturation, adsorption on external surface occurs.

Dissolution rate enhancement of fenofibrate using liquisolid tablet technique. Initially the liquid is absorbed in the interior of the particles captured by its internal structure and after saturation of this process adsorption of the liquid onto the internal and external surfaces of the porous carrier particles occurs Rania et al.

Ammar Said Suliman, Rosaleen J.


Merits of this approach include low costing, simple processing for the formulation of oily liquid drugs, great potentials in industrial production, possess enhanced in vitro drug release as compared to capsules dosage form. This procedure involves the fixed height of each liquisolid powder substrate with prepared and fixed weight. After complete formulation liquisolid tablets also get evaluated for wt.

Liquisolid system demonstrated for drugs which would enhance the dissolution profile and the absorption capacity of water insoluble solid drugs such as digoxin, digitoxin, prednisolone, hydrocortisone, famotidine, carbamazepine, water insoluble vitamins, hydrochlorothiazide, Domperadone, spiranolactone, Technqiue, Naproxen, and Meloxicam.


Adsorption is the phenomenon in which liquid is not truly absorbed and instead of being dispersed through out the interior of the solid, the molecules only cling to its available surface, internal and external.

Concept of liquisolid technique: Determination of angle of slide is done by weighing the required amount of carrier material and placed at one end of a metal plate with a polished surface. This end was raised gradually until the plate formed an angle with the horizontal at which the powder was about to slide. The final mixture is then allowed to compress by using tablet compression machine.

As highest drug release rates are observed with liquisolid compacts containing a drug solution as liquid portion, liquisolid compacts techniquw be optimized by selection of the liquid vehicle and the carrier and coating materials.

To evaluate any interaction between indomethacin and the other components in liquisolid formulations, X-ray powder diffraction XPD and differential scanning calorimetry DSC were used. There are three basic technologies currently in use to prepare nanoparticles.

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Micronization is the most common method used to increase the surface area of the drug, but this becomes less effective when they are formulated as tablets liquieolid encapsulations Aguiar et al. Classification of liquisolid techniques: Salts have improved solubility and dissolution as compared to the original drug.

Vallabh Prakashan, Delhi, India; Lower production cost than that of soft gelatin capsules. This entails the optimization of the hardness of the Liquisolid tablet, without applying excessive compression force yet assuring rapid disintegration liqujsolid dissolution. Abstract Liquisolid technique is also known as powder solution technology. Liquisolid is mainly composed of drug, non volatile solvent, carrier material, coating material, and disintegrant.

In order to ensure the suitability of the selected excipients, Fourier Transform Infra Red Spectroscopy, Differential scanning Calorimetry, X-ray Diffraction and Scanning Electron Microscope studies are to be performed. It is the liquisoliv which deals with the solubility enhancement of poorly soluble drugs. In this technique, the drug is dissolved in an organic solvent followed by soaking of the solution by a high surface area carrier such as silica.


Pharmaceutical applications of liquisolid technique

Several studies have been carried out to increase the dissolution rate of drugs by decreasing the particle size, by creating nanoparticles and microparticles. This study suggested that Avicel had more liquid retention potential due to the high specification area of Avicel 1.

Scanning electron microscopy shows that there is presence or absence of crystal form of the drug or excipients in the formulation. There are several approaches for solubility enhancement which includes micronization, Nanonisation, use of salt forms, use of surfactant, solid dispersion, and supercritical fluid recrystalization etc.

Further decrease in the ratio of microcrystalline cellulose: Production of liquisolid system is similar to that of conventional tablets.

Absence of constructive specific peaks of the drug in the liquisolid compacts in X-ray diffractogram specify that drug has almost entirely converted from crystalline to amorphous or solubilised form. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.

The results showed that aging had no significant effect on dissolution profiles of liquisolid tablets.

In-vivo evaluation of hydrochlorothiazide liquisolid tablet in beagles dogs. Liquisolid tablets demonstrated significantly faster drug dissolution patterns in small volumes of dissolution media such as mL and mL Studies by Javadzadeh Y.